EFFECTS OF THE ANTIDEPRESSANT ANTIPANIC DRUG PHENELZINE ON GABA CONCENTRATIONS AND GABA-TRANSAMINASE ACTIVITY IN RAT-BRAIN

被引：43

作者：

MCMANUS, DJ

BAKER, GB

MARTIN, IL

GREENSHAW, AJ

MCKENNA, KF

机构：

[1] UNIV ALBERTA,DEPT PSYCHIAT,NEUROCHEM RES UNIT,EDMONTON T6G 2B7,ALBERTA,CANADA

[2] MRC,NEUROBIOL UNIT,CAMBRIDGE CB2 2QH,ENGLAND

来源：

BIOCHEMICAL PHARMACOLOGY | 1992年 / 43卷 / 11期

关键词：

D O I：

10.1016/0006-2952(92)90331-C

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The effects of long-term (28-day) administration of several antidepressant/antipanic drugs [imipramine, desipramine, tranylcypromine and phenelzine (PLZ) on gamma-aminobutyric acid-transaminase (GABA-T) activity and GABA levels were investigated in rat frontal cortex. Of the drugs investigated, only PLZ inhibited GABA-T and elevated GABA levels. Additional short-term experiments were conducted with PLZ, and they demonstrated a dose-dependent inhibition of GABA-T in rat whole brain. Time-response studies on inhibition of GABA-T in whole brain demonstrated that at a dose of PLZ of 15 mg/kg i.p. inhibition of GABA-T remained relatively constant from 1 to 8 hr and that the enzyme was still inhibited by 23% at 24 hr after PLZ administration.

引用

页码：2486 / 2489

页数：4

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