BIOSYNTHETIC PRECURSORS OF VALCLAVAM

被引：9

作者：

BALDWIN, JE ^{[1
]}

GOH, KC ^{[1
]}

SCHOFIELD, CJ ^{[1
]}

机构：

[1] OXFORD CTR MOLEC SCI,OXFORD OX1 3QY,ENGLAND

来源：

TETRAHEDRON LETTERS | 1994年 / 35卷 / 17期

关键词：

D O I：

10.1016/S0040-4039(00)77031-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The biosynthesis of valclavan was investigated by feeding radiolabelled potential precursors to fermentations of Streptomyces antibioticus ssp antibioticus Tu 1718. The preliminary results indicate that the primary metabolic precursors of valclavam are L-valine, L-arginine. L-methionine and a 3-C pool metabolite and suggest a common biosynthetic origin for clavulanic acid and valclavam.

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页码：2779 / 2782

页数：4

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