REVISED STRUCTURES FOR TU 1718B AND VALCLAVAM

被引:15
作者
BALDWIN, JE
CLARIDGE, TDW
GOH, KC
KEEPING, JW
SCHOFIELD, CJ
机构
[1] DYSON PERRINS LAB,S PARKS RD,OXFORD OX1 3QY,ENGLAND
[2] OXFORD CTR MOLEC SCI,OXFORD OX1 3QY,ENGLAND
关键词
D O I
10.1016/S0040-4039(00)73905-0
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
The structures of Tu 1718B and valclavam, antibiotics produced by Streptomyces antibioticus ssp. antibioticus Tu 1718, have been reassigned as valyl-beta-delta-dihydroxylysine (4) and the clavam (5) respectively, on the basis of NMR experiments and the observation that the former is a degradation product of the latter.
引用
收藏
页码:5645 / 5648
页数:4
相关论文
共 13 条
[1]  
Baldwin J. E., 1992, CHEM BETA LACTAMS, P1
[2]   A SUBSTRATE-ANALOG STUDY ON CLAVAMINIC ACID SYNTHASE - POSSIBLE CLUES TO THE BIOSYNTHETIC ORIGIN OF PROCLAVAMIC ACID [J].
BALDWIN, JE ;
LLOYD, MD ;
WHASON, B ;
SCHOFIELD, CJ ;
ELSON, SW ;
BAGGALEY, KH ;
NICHOLSON, NH .
JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1993, (06) :500-502
[3]   H-1 AND C-13 ASSIGNMENTS FROM SENSITIVITY-ENHANCED DETECTION OF HETERONUCLEAR MULTIPLE-BOND CONNECTIVITY BY 2D MULTIPLE QUANTUM NMR [J].
BAX, A ;
SUMMERS, MF .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1986, 108 (08) :2093-2094
[4]   SENSITIVITY-ENHANCED TWO-DIMENSIONAL HETERONUCLEAR SHIFT CORRELATION NMR-SPECTROSCOPY [J].
BAX, A ;
SUBRAMANIAN, S .
JOURNAL OF MAGNETIC RESONANCE, 1986, 67 (03) :565-569
[5]   ENANTIOSELECTIVE TOTAL SYNTHESIS OF THE FUNGICIDE BETA-LACTAM ANTIBIOTIC (-)-(2S,5S)-2-(2-HYDROXYETHYL)CLAVAM AND ITS (+)-(2S,5R)-EPIMER [J].
HOPPE, D ;
HILPERT, T .
TETRAHEDRON, 1987, 43 (11) :2467-2474
[6]   COMMON ORIGIN OF CLAVULANIC ACID AND OTHER CLAVAM METABOLITES IN STREPTOMYCES [J].
IWATAREUYL, D ;
TOWNSEND, CA .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1992, 114 (07) :2762-2763
[7]  
KERN A, 1989, LIEBIGS ANN CHEM, P361
[8]  
PETER H, 1985, Patent No. 3427651
[9]  
Peter H., 1985, RECENT ADV CHEMOTHER, P237
[10]  
PETER H, 1992, COMMUNICATION