CLINICAL-APPLICATIONS OF FLUORESCENCE INSITU HYBRIDIZATION

被引：80

作者：

TKACHUK, DC

PINKEL, D

KUO, WL

WEIER, HU

GRAY, JW

机构：

[1] UNIV CALIF LAWRENCE LIVERMORE NATL LAB,DIV BIOMED SCI,POB 5507,LIVERMORE,CA 94550

[2] STANFORD UNIV,MED CTR,DEPT PATHOL,STANFORD,CA 94305

来源：

GENETIC ANALYSIS-BIOMOLECULAR ENGINEERING | 1991年 / 8卷 / 02期

关键词：

D O I：

10.1016/1050-3862(91)90051-R

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

We review here the application of fluorescence in situ hybridization with chromosome-specific probes to chromosome classification and to detection of changes in chromosome number or structure associated with genetic disease. Information is presented on probe types that are available for disease detection. We discuss the application of these probes to detection of numerical aberrations important for prenatal diagnosis and to detection and characterization of numerical and structural aberrations in metaphase spreads and in interphase nuclei to facilitate tumor diagnosis.

引用

页码：67 / 74

页数：8

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