EFFECTS OF THE NOVELTY OR FAMILIARITY OF VISUAL-STIMULI ON THE EXPRESSION OF THE IMMEDIATE-EARLY GENE C-FOS IN RAT-BRAIN

被引:160
作者
ZHU, XO
BROWN, MW
MCCABE, BJ
AGGLETON, JP
机构
[1] UNIV BRISTOL,DEPT ANAT,BRISTOL BS8 1TD,AVON,ENGLAND
[2] UNIV CAMBRIDGE,DEPT ZOOL,CAMBRIDGE CB2 3EJ,ENGLAND
[3] UNIV WALES COLL CARDIFF,DEPT PSYCHOL,CARDIFF CF1 3YG,S GLAM,WALES
基金
英国医学研究理事会; 英国生物技术与生命科学研究理事会;
关键词
LEARNING; MEMORY; RECOGNITION; VISUAL CORTEX; RHINAL CORTEX; HIPPOCAMPUS; PREFRONTAL CORTEX; THALAMUS;
D O I
10.1016/0306-4522(95)00320-I
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
To investigate substrates of recognition memory, the cellular expression of Fos protein in rat brain has been studied after groups of rats were either shown sets of novel or highly familiar objects, or were exposed to the same pattern of illumination without objects being shown. Counts of stained nuclei were made in eight brain regions, where information about novel or familiar visual stimuli is likely to be processed or stored. The counts were relatively high in occipital visual association cortex and area TE of temporal cortex, intermediate in perirhinal cortex, entorhinal cortex, anterior cingulate cortex and the diagonal band of Broca, and low in the hippocampal formation and mediodorsal nucleus of the thalamus. The number of Fos-stained cells was significantly higher for the rats shown novel objects than for those shown familiar objects in perirhinal cortex, area TE, occipital cortex and anterior cingulate cortex. Arguments are advanced that these differences in counts indicate areas involved in the processing and/or storage of information about the novelty or familiarity of visual stimuli, information important to recognition memory.
引用
收藏
页码:821 / 829
页数:9
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