LIPOPOLYSACCHARIDE INTERFERES WITH THE INDUCTION OF PERIPHERAL T-CELL DEATH

被引:220
作者
VELLA, AT
MCCORMACK, JE
LINSLEY, PS
KAPPLER, JW
MARRACK, P
机构
[1] UNIV COLORADO,HLTH SCI CTR,DEPT IMMUNOL,DENVER,CO 80206
[2] UNIV COLORADO,HLTH SCI CTR,DEPT MED,DENVER,CO 80206
[3] UNIV COLORADO,HLTH SCI CTR,DEPT BIOCHEM BIOPHYS & GENET,DENVER,CO 80206
[4] BRISTOL MYERS SQUIBB PHARMACEUT RES INST,SEATTLE,WA 98121
关键词
D O I
10.1016/1074-7613(95)90050-0
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
In mice injected with superantigens, T cells specific for that antigen proliferate and then die. It has been suggested that the target cells die because they encounter superantigen on the surfaces of nonprofessional presenting cells, such as B cells, which cannot deliver costimulatory signals to T cells. A number of reagents that induce costimulatory molecules on B cells were tested. Lipopolysaccharide very effectively prevented T cell death driven by superantigen. Perhaps surprisingly, the action of lipopolysaccharide was not mediated through the expected costimulatory molecule, B7. Rather, the effects of lipopolysaccharide involved the production of inflammatory cytokines, in particular TNF alpha. The rescued cells survived in vitro culture and were resistant to Pas-induced killing. These data demonstrate that LPS can block antigen-induced T cell death perhaps by interfering with Fas signaling.
引用
收藏
页码:261 / 270
页数:10
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