CARDIOVASCULAR SENSITIVITY CHANGES TO EICOSANOIDS IN RATS WITH EXPERIMENTALLY INDUCED DIABETES-MELLITUS

被引：7

作者：

HODGSON, WC

SIKORSKI, BW

KING, RG

机构：

[1] Department of Pharmacology, Monash University, Clayton, Victoria

来源：

CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY | 1992年 / 19卷 / 01期

关键词：

ALDOSE REDUCTASE INHIBITORS; ALLOXAN; ARACHIDONIC ACID; DIABETES-MELLITUS; PROSTACYLIN; STREPTOZOTOCIN; THROMBOXANE;

D O I：

10.1111/j.1440-1681.1992.tb00391.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

This paper attempts to provide a short review of the evidence for: 1. Increased platelet production of thromboxane A2 and reduced vascular production of prostacyclin in the human and also animal models of diabetes. 2. Reduced depressor responsiveness to arachidonic acid of anaesthetized alloxan- and streptozotocin-induced diabetic rats. 3. Enhanced constrictor responsiveness to arachidonic acid in blood-perfused hindquarters of alloxan-induced diabetic rats. 4. Potentiation by the thromboxane A2-mimetic, U46619, of constrictor responses to 5-hydroxytryptamine in Krebs'-perfused hindquarters and kidneys of both control and alloxan-induced diabetic rats. 5. Alterations during diabetes in production of, and responsiveness to, eicosanoids may contribute to the cardiovascular changes which occur in this disease.

引用

页码：9 / 15

页数：7

共 57 条

[21] DECREASED VASCULAR PROSTACYCLIN IN EXPERIMENTAL DIABETES [J].