NOVEL 1,6-ANHYDRO-BETA-LACTOSE DERIVATIVES FOR RAPID AND EFFICIENT SYNTHESES OF OLIGOSACCHARIDE SEQUENCES CONTAINING N-ACETYLLACTOSAMINE

被引：13

作者：

NISHIMURA, SI

MURAYAMA, S

KURITA, K

KUZUHARA, H

机构：

[1] INST PHYS & CHEM RES, WAKO, SAITAMA 35101, JAPAN

[2] SEIKEI UNIV, FAC ENGN, DEPT IND CHEM, MUSASHINO, TOKYO 180, JAPAN

来源：

CHEMISTRY LETTERS | 1992年 / 08期

关键词：

D O I：

10.1246/cl.1992.1413

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Fully functionalized glycosyl acceptors for the efficient syntheses of cell-surface carbohydrate determinants containing N-acetyllactosamine have been systematically prepared by the regioselective manipulations of a readily available 1,6-anhydro-6'-O-trityl-beta-lactose as a key starting material. Versatility of the standardized intermediates having an unprotected hydroxyl group C-3 or C-2' position are also preliminarily demonstrated by the glycoside formation with the known fucose derivatives.

引用

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页码：1413 / 1416

页数：4

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