A COMPARISON OF THE PROPERTIES AND ENZYMATIC-ACTIVITIES OF 3 ANGIOTENSIN PROCESSING ENZYMES - ANGIOTENSIN-CONVERTING ENZYME, PROLYL ENDOPEPTIDASE AND NEUTRAL ENDOPEPTIDASE 24.11

被引:250
作者
WELCHES, WR [1 ]
BROSNIHAN, KB [1 ]
FERRARIO, CM [1 ]
机构
[1] BOWMAN GRAY SCH MED, CTR HYPERTENS, DEPT SURG SCI, WINSTON SALEM, NC 27157 USA
关键词
D O I
10.1016/0024-3205(93)90108-F
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
The discovery of angiotensin-(1-7) [Ang-(1-7)] as a bioactive Ang II fragment of the renin-angiotensin system (RAS) alters the current understanding of the enzymatic components that comprise the RAS cascade. Two neutral endopeptidases, prolyl endopeptidase (E.C. 3.4.21.26) and neutral endopeptidase 24.11 (E.C. 3.4.24.11), are capable of forming Ang-(1-7) from Ang I and have been implicated in the in vivo processing of Ang I. This makes them putative Ang processing enzymes and part of the RAS cascade. This review summarizes the physical characteristics and distribution of angiotensin converting enzyme (E.C. 3.4.15.1), a known Ang I processing enzyme, and compares its features to what is known of prolyl endopeptidase and neutral endopeptidase 24.11.
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页码:1461 / 1480
页数:20
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共 159 条
[11]   AN EVALUATION OF THE ROLE OF A PYROGLUTAMYL PEPTIDASE, A POST-PROLINE CLEAVING ENZYME AND A POST-PROLINE DIPEPTIDYL AMINO PEPTIDASE, EACH PURIFIED FROM THE SOLUBLE FRACTION OF GUINEA-PIG BRAIN, IN THE DEGRADATION OF THYROLIBERIN INVITRO [J].
BROWNE, P ;
OCUINN, G .
EUROPEAN JOURNAL OF BIOCHEMISTRY, 1983, 137 (1-2) :75-87
[12]  
BULL HG, 1985, J BIOL CHEM, V260, P2963
[13]   ACTIVATION OF ANGIOTENSIN CONVERTING ENZYME BY MONO-VALENT ANIONS [J].
BUNNING, P ;
RIORDAN, JF .
BIOCHEMISTRY, 1983, 22 (01) :110-116
[15]  
BUNNING P, 1981, ISRAEL J CHEM, V21, P43
[16]   INVOLVEMENT OF ENDO-OLIGOPEPTIDASE-A AND ENDO-OLIGOPEPTIDASE-B IN THE DEGRADATION OF NEUROTENSIN BY RABBIT BRAIN [J].
CAMARGO, ACM ;
ALMEIDA, MLC ;
EMSON, PC .
JOURNAL OF NEUROCHEMISTRY, 1984, 42 (06) :1758-1761
[17]  
CAMARGO ACM, 1979, J BIOL CHEM, V254, P5304
[18]   CARDIOVASCULAR EFFECTS OF ANGIOTENSIN-(1-7) INJECTED INTO THE DORSAL MEDULLA OF RATS [J].
CAMPAGNOLESANTOS, MJ ;
DIZ, DI ;
SANTOS, RAS ;
KHOSLA, MC ;
BROSNIHAN, KB ;
FERRARIO, CM .
AMERICAN JOURNAL OF PHYSIOLOGY, 1989, 257 (01) :H324-H329
[19]   PURIFICATION OF RABBIT BRAIN ENDOOLIGOPEPTIDASES AND PREPARATION OF ANTI-ENZYME ANTIBODIES [J].
CARVALHO, KM ;
CAMARGO, ACM .
BIOCHEMISTRY, 1981, 20 (25) :7082-7088
[20]  
CASCIERI MA, 1984, MOL PHARMACOL, V25, P287