INSULIN-MEDIATED ACTIVATION OF GLYCOGEN-SYNTHASE IN ISOLATED SKELETAL-MUSCLE - ROLE OF MITOCHONDRIAL RESPIRATION

被引：12

作者：

KATZ, A ^{[1
]}

WESTERBLAD, H ^{[1
]}

机构：

[1] KAROLINSKA INST,DEPT PHYSIOL & PHARMACOL,S-17177 STOCKHOLM,SWEDEN

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS | 1995年 / 1244卷 / 01期

关键词：

ATP; PHOSPHOCREATINE; HYPOXIA; CYANIDE; (M-SOLEUS);

D O I：

10.1016/0304-4165(95)00050-L

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Activation of glycogen synthase (GS) by insulin in isolated, aerated muscle was abolished when oxygen was replaced by nitrogen. Reoxygenation of the muscle after prior exposure to nitrogen restored the insulin effect. In the presence of cyanide (inhibitor of mitochondrial respiration) insulin did not activate GS. These data demonstrate that adequate mitochondrial respiration is required for insulin-mediated activation of GS.

引用

页码：229 / 232

页数：4