LACK OF AN ASSOCIATION BETWEEN APOLIPOPROTEIN-E EPSILON-4 AND ALZHEIMERS-DISEASE IN ELDERLY NIGERIANS

被引：136

作者：

OSUNTOKUN, BO

SAHOTA, A

OGUNNIYI, AO

GUREJE, O

BAIYEWU, O

ADEYINKA, A

OLUWOLE, SO

KOMOLAFE, O

HALL, KS

UNVERZAGT, FW

HUI, SL

YANG, M

HENDRIE, HC

机构：

[1] INDIANA UNIV,SCH MED,DEPT PSYCHIAT,INDIANAPOLIS,IN 46202

[2] UNIV IBADAN,DEPT MED,NEUROL UNIT,IBADAN,NIGERIA

[3] UNIV IBADAN,DEPT PREVENT & SOCIAL MED,IBADAN,NIGERIA

[4] INDIANA UNIV,SCH MED,DEPT MED,INDIANAPOLIS,IN

[5] INDIANA UNIV,SCH MED,DEPT GENET,INDIANAPOLIS,IN

来源：

ANNALS OF NEUROLOGY | 1995年 / 38卷 / 03期

关键词：

D O I：

10.1002/ana.410380319

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

As part of a community-based study of Alzheimer's Disease (AD) in a Nigerian population aged 65 years and over, we have determined apolipoprotein E (APOE) genotypes on 56 subjects (39 controls and 17 subjects with dementia, including 12 with AD). The epsilon 4 allele of APOE was not associated with AD or dementia in this community-based sample. The epsilon 4 allele frequency was 17.6% in demented patients and 16.7% in AD patients compared with 20.5% in the control subjects. These findings are in marked contrast to the strong association between the epsilon 4 allele and AD in our previously reported study with African Americans.

引用

页码：463 / 465

页数：3

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