APOLIPOPROTEIN-E GENOTYPES AND ALZHEIMERS-DISEASE IN A COMMUNITY STUDY OF ELDERLY AFRICAN-AMERICANS

被引：128

作者：

HENDRIE, HC

HALL, KS

HUI, S

UNVERZAGT, FW

YU, CE

LAHIRI, DK

SAHOTA, A

FARLOW, M

MUSICK, B

CLASS, CA

BRASHEAR, A

BURDINE, VE

OSUNTOKUN, BO

OGUNNIYI, AO

GUREJE, O

BAIYEWU, O

SCHELLENBERG, GD

机构：

[1] INDIANA UNIV,SCH MED,DEPT NEUROL,INDIANAPOLIS,IN 46202

[2] INDIANA UNIV,SCH MED,DEPT MED & MOLEC GENET,INDIANAPOLIS,IN 46202

[3] UNIV WASHINGTON,DEPT MED,DIV NEUROL,SEATTLE,WA

[4] UNIV IBADAN,DEPT MED,NEUROL UNIT,IBADAN,NIGERIA

[5] UNIV IBADAN,DEPT PREVENT & SOCIAL MED,IBADAN,NIGERIA

来源：

ANNALS OF NEUROLOGY | 1995年 / 37卷 / 01期

关键词：

D O I：

10.1002/ana.410370123

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

As part of a community-based study of Alzheimer's disease (AD) in the African-American population age 65 and over, we have determined apolipoprotein E (Apo E) genotypes in 85 subjects (31 AD patients and 54 controls). The epsilon 4 allele of Apo E was strongly associated with AD in this population sample. The epsilon 4 allele frequency in AD patients was 40.3% compared with 23.9% in the control group, and 22.6% of the AD patients were homozygous for this allele compared with 3.7% of the control subjects (p = 0.01). This study extends the association of Apo E-epsilon 4 and AD to nonwhite populations and provides further evidence that the observed allelic association is biologically relevant.

引用

页码：118 / 120

页数：3

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