DRUG-INDUCED PARKINSONISM - A REVIEW

被引:92
作者
MONTASTRUC, JL [1 ]
LLAU, ME [1 ]
RASCOL, O [1 ]
SENARD, JM [1 ]
机构
[1] FAC MED TOULOUSE, CTR MIDIPYRENEES PHARMACOVIGILANCE & INFORMAT MED, F-31073 TOULOUSE, FRANCE
关键词
PARKINSONS DISEASE; PARKINSONISM; SIDE EFFECTS; PHARMACOVIGILANCE; NEUROLEPTICS; CALCIUM CHANNEL BLOCKERS;
D O I
10.1111/j.1472-8206.1994.tb00808.x
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
The main clinical features, pathophysiology and underlying mechanisms of drug-induced parkinsonism are reviewed. The clinical manifestations of drug-induced parkinsonism are often indistinguishable from idiopathic Parkinson's disease. However, some subtle differences may exist: for example drug-induced parkinsonism is often associated with tardive dyskinesias, bilateral symptoms and the absence of resting tremor, etc. Besides toxins leg manganese, carbon monoxide or MPTP), many drugs are known to produce parkinsonism: dopamine blocking drugs (true neuroleptics used as antipsychotics: phenothiazines, butyrophenones, thioxanthenes but also sulpiride, ''hidden'' neuroleptics prescribed as anti-nausea or anti-vomiting drugs (such as metoclopramide and other benzamide derivatives), dopamine depleting drugs (reserpine, tetrabenazine), alpha-methyldopa, calcium channel blockers (flunarizine, cinnarizine, etc). The putative role of other drugs (eg fluoxetine, lithium, amiodarone) as well as the therapeutic management of this side effect are reviewed.
引用
收藏
页码:293 / 306
页数:14
相关论文
共 129 条
[31]  
DITRABER J, 1986, LANCET, V2, P292
[32]  
EDELSTEIN H, 1987, LANCET, V2, P341
[33]  
EUVRARD C, 1980, J PHARMACOL EXP THER, V214, P179
[34]   DIFFERENT EFFECTS OF THE CALCIUM-ANTAGONISTS NIMODIPINE AND FLUNARIZINE ON DOPAMINE METABOLISM IN THE RAT-BRAIN [J].
FADDA, F ;
GESSA, GL ;
MOSCA, E ;
STEFANINI, E .
JOURNAL OF NEURAL TRANSMISSION, 1989, 75 (03) :195-200
[35]   CATATONIA DUE TO DISULFIRAM TOXICITY [J].
FISHER, CM .
ARCHIVES OF NEUROLOGY, 1989, 46 (07) :798-804
[36]   PARKINSONISM ASSOCIATED WITH INTRAVENTRICULAR AMPHOTERICIN-B [J].
FISHER, JF ;
DEWALD, J .
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 1983, 12 (01) :97-99
[37]   INDUCTION OF PARKINSONISM BY INTRAVENTRICULAR BETHANECHOL IN A PATIENT WITH ALZHEIMERS-DISEASE [J].
FOX, JH ;
BENNETT, DA ;
GOETZ, CG ;
PENN, RD ;
SAVOY, S ;
CLASEN, R ;
WILSON, RS .
NEUROLOGY, 1989, 39 (09) :1265-1265
[38]   CLOZAPINE IN THE TREATMENT OF PSYCHOSIS IN PARKINSONS-DISEASE [J].
FRIEDMAN, JH ;
LANNON, MC .
NEUROLOGY, 1989, 39 (09) :1219-1221
[39]  
GALLAND MC, 1983, THERAPIE, V38, P465
[40]   PARKINSONISM UNMASKED BY VERAPAMIL [J].
GARCIAALBEA, E ;
JIMENEZJIMENEZ, FJ ;
AYUSOPERALTA, L ;
CABRERAVALDIVIA, F ;
VAQUERO, A ;
TEJEIRO, J .
CLINICAL NEUROPHARMACOLOGY, 1993, 16 (03) :263-265