NEUROPHYSIOLOGICAL AND BIOCHEMICAL-CHANGES EVOKED BY VALPROIC ACID IN THE CENTRAL-NERVOUS-SYSTEM

被引：39

作者：

COTARIU, D

ZAIDMAN, JL

EVANS, S

机构：

[1] Department of Biochemical Pathology, Assaf Harofeh Medical Center, Sackler Faculty of Medicine, Zerifin

来源：

PROGRESS IN NEUROBIOLOGY | 1990年 / 34卷 / 04期

关键词：

D O I：

10.1016/0301-0082(90)90010-E

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

(1) Valproic acid is an anticonvulsant agent widely used in the management of various forms of epilepsy, including absence, myoclonic and tonic-clonic seizures. (2) It also has anticonvulsant potency in a wide variety of animal models of epilepsy. (3) This action is generally thought to be exerted through modulation of the activity of the endogenous inhibitory neurotransmitter, γ-aminobutyric acid. (4) Evidence that valproic acid interacts with the γ-aminobutyric acid system is presented. (5) Interactions of valproic acid with other neurotransmitters, i.e. aspartate, glutamate, taurine, serotonin, as well as with cyclic nucleotides and hormones are also considered. (6) Direct effects of valproic acid on excitable membranes and its relationships with analgesia are outlined. © 1990.

引用

页码：343 / 354

页数：12

共 171 条

[81] ANTIEPILEPTIC DRUG DEVELOPMENT .2. ANTICONVULSANT DRUG SCREENING [J].