ACUTELY ADMINISTERED HALOPERIDOL-INDUCED PATTERN CHANGES OF REGIONAL CEREBRAL BLOOD-FLOW IN SCHIZOPHRENICS - OBSERVATION FROM SUBTRACTION OF BRAIN IMAGING WITH SINGLE PHOTON-EMISSION COMPUTED-TOMOGRAPHY USING TC-99M HEXAMETHYL-PROPYLENEAMINE OXIME

被引：12

作者：

JIBIKI, I ^{[1
]}

MATSUDA, H ^{[1
]}

YAMAGUCHI, N ^{[1
]}

KUROKAWA, K ^{[1
]}

HISADA, K ^{[1
]}

机构：

[1] KANAZAWA UNIV, SCH MED, DEPT NUCL MED, KANAZAWA, ISHIKAWA 920, JAPAN

来源：

NEUROPSYCHOBIOLOGY | 1992年 / 25卷 / 04期

关键词：

SCHIZOPHRENICS; SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY; TC-99M HEXAMETHYLPROPYLENEAMINE OXIME; REGIONAL CEREBRAL BLOOD FLOW;

D O I：

10.1159/000118834

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Changes in regional cerebral blood flow in brain images with single photon emission computed tomography using technetium-99m hexamethyl-propyleneamine oxime before and after intramuscular injection of haloperidol (0.08 mg/kg) were studied in 5 medicated subjects in their twenties, consisting of 5 schizophrenics and 1 patient with histrionic personality disorder, by a subtraction method of brain images. The haloperidol injection induced two types of perfusion pattern change; in 2 of the schizophrenics, a relative hypoperfusion in the frontal lobes in the images prior to injection was converted to a relative hyperperfusion. In the other 3 schizophrenics and in the patient with histrionic personality disorder, the slight left hemispheric dominance was changed to a marked right hemispheric dominance. The results indicate that haloperidol affects perfusion patterns in schizophrenics.

引用

页码：182 / 187

页数：6

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