CARBON-CARBON BOND FORMATION MEDIATED BY PAPAIN CHEMICALLY MODIFIED BY THIAZOLIUM SALTS

被引：23

作者：

SUCKLING, CJ

ZHU, LM

机构：

[1] Department of Pure and Applied Chemistry, University of Strathclyde, Glasgow

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1993年 / 3卷 / 04期

关键词：

D O I：

10.1016/S0960-894X(01)81221-X

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Alkylation of the active site cysteine with 2-bromomethyl-N-methyl- or 2-bromomethyl-N-benzyl-thiazolium bromide afforded a protein with no detectable protease activity but the ability to mediate carbon-carbon bond formation with or 6-oxoheptanal as substrate.

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页码：531 / 534

页数：4

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