OCCURRENCE OF LOOSELY BOUND MERCURY IN THE BLOOD OF GUINEA-PIG TREATED WITH METHYLMERCURIC CHLORIDE

被引：1

作者：

UDA, Y

NAKAZAWA, Y

机构：

[1] Department of Chemical Toxicology, Medical Research Institute, Tokyo Medical and Dental University, Tokyo 101, 2-3-10 Kanda-Surugadai, Chiyoda-ku

来源：

JOURNAL OF PHARMACOBIO-DYNAMICS | 1979年 / 2卷 / 04期

关键词：

chloroform-methanol extraction; guinea pig; mercuric chloride; methylmercuric chloride; proteolipid;

D O I：

10.1248/bpb1978.2.245

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Guinea pigs were given 203Hg-labeled methylmercuric chloride or mercuric chloride and then the distribution of mercury in the blood, brain and liver was investigated. The methylmercury in the blood and brain was extracted with a chloroform-methanol mixture. Most of the extractable mercury from the blood was detected in the proteolipid fraction by further fractionation. The mercury in the chloroform-methanol extract was also dialyzable against the same solvent. These findings suggest the occurrence of loosely bound mercury in the blood after administration of methylmercury. © 1979, The Pharmaceutical Society of Japan. All rights reserved.

引用

页码：245 / 250

页数：6

共 14 条

[1]

BERGLUND F, 1969, CHEMICAL FALLOUT CUR, P258

[2]

FOLCH J, 1951, J BIOL CHEM, V191, P807

[3]

Hirayama K, 1975, Kumamoto Med J, V28, P151

[4] METHYL MERCURY - ACUTE TOXICITY, TISSUE DISTRIBUTION AND DECAY PROFILES IN GUINEA-PIG [J].

IVERSON, F ;

DOWNIE, RH ;

PAUL, C ;

TRENHOLM, HL .

TOXICOLOGY AND APPLIED PHARMACOLOGY, 1973, 24 (04) :545-554

[5] METHYLMERCURY BINDS TO A LOW-MOLECULAR WEIGHT SUBSTANCE IN RABBIT AND HUMAN-ERYTHROCYTES [J].

NAGANUMA, A ;

IMURA, N .

TOXICOLOGY AND APPLIED PHARMACOLOGY, 1979, 47 (03) :613-616

[6]

SOMJEN GG, 1973, J PHARMACOL EXP THER, V187, P602

[7]

SUZUKI T, 1969, CHEM FALLOUT, P245

[8]

SUZUKI TSUGUYOSHI, 1967, IND HEALTH, V5, P149

[9] DISTRIBUTION OF INORGANIC ARYL AND ALKYL MERCURY COMPOUNDS IN RATS [J].

TAKEDA, Y ;

KUNUGI, T ;

HOSHINO, O ;

UKITA, T .

TOXICOLOGY AND APPLIED PHARMACOLOGY, 1968, 13 (02) :156-&

[10] MERCURY COMPOUNDS IN BLOOD OF RATS TREATED WITH ETHYLMERCURIC CHLORIDE [J].

TAKEDA, Y ;

KUNUGI, T ;

TERAO, T ;

UKITA, T .

TOXICOLOGY AND APPLIED PHARMACOLOGY, 1968, 13 (02) :165-&

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