EFFECTS OF PSYCHOTROPIC-DRUGS ON PRESSOR AND BEHAVIORAL-RESPONSES TO BRAIN-STIMULATION IN UNRESTRAINED, UNANESTHETIZED RATS

被引：25

作者：

KAWASAKI, H ^{[1
]}

WATANABE, S ^{[1
]}

UEKI, S ^{[1
]}

机构：

[1] KYUSHU UNIV,FAC PHARMACEUT SCI,DEPT PHARMACOL,FUKUOKA 812,JAPAN

来源：

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR | 1979年 / 10卷 / 06期

关键词：

Behavior; Blood pressure; Brain stimulation; Chlorpromazine; Diazepam; Imipramine; Mesencephalic reticular formation; Pentobarbital; Posterior hypothalamus; Psychotropic drugs; Rat;

D O I：

10.1016/0091-3057(79)90066-2

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

Electrical stimulation of the posterior hypothalamus (PH) and the mesencephalic reticular formation (MRF) in unanesthetized, unrestrained rats with chronic electrode implants and an arterial cannula elictied a rise in blood pressure accompanied by behavioral changes such as exploration, flight or escape responses. Pentobarbital inhibited both the pressor and behavioral responses to PH and MRF stimulation. Chlorpromazine, diazepam and imipramine depressed the pressor response to PH stimulation rather than that to MRF stimulation with affecting the behavioral responses. It is concluded from these results that chlorpromazine, diazepam and imipramine exert their action on the neural pathway involved in the pressor response rather than on that inducing behavioral responses, whereas pentobarbital affects more extended brain areas related to these neural systems. © 1979.

引用

页码：907 / 915

页数：9

共 22 条

[11]

KILLAM EK, 1962, PHARMACOL REV, V14, P175

[12]

MIZOGAMI S, 1969, JAPAN J CONST MED, V32, P59

[13] PHARMACOLOGICAL MODIFICATIONS OF SYMPATHETIC RESPONSES ELICITED BY HYPOTHALAMIC STIMULATION IN RAT [J].

MORPURGO, C .

BRITISH JOURNAL OF PHARMACOLOGY, 1968, 34 (03) :532-&

[14] EFFECTS OF SODIUM PENTOBRARBITAL ON ELECTRICAL + REFLEX ACTIVATION OF CARDIOVASCULAR SYSTEM [J].

PEISS, CN ;

MANNING, JW .

CIRCULATION RESEARCH, 1964, 14 (03) :228-&

[15] IMPORTANCE OF ADRENERGIC NEURONS OF BRAIN FOR RISE OF BLOOD PRESSURE EVOKED BY HYPOTHALAMIC STIMULATION [J].

PRZUNTEK, H ;

GUIMARAES, S ;

PHILIPPU, A .

NAUNYN-SCHMIEDEBERGS ARCHIV FUR PHARMAKOLOGIE, 1971, 271 (03) :311-+

[16]

SCHALLEK W, 1966, ARCH INT PHARMACOD T, V161, P126

[17]

SCHMITT H, 1966, INT S ANTIDEPRESSANT, P104

[18] SELECTIVE EFFECT OF DIAZEPAM ON CERTAIN CENTRAL SYMPATHETIC COMPONENTS [J].

SIGG, EB ;

KEIM, KL ;

KEPNER, K .

NEUROPHARMACOLOGY, 1971, 10 (05) :621-&

[19]

SIGG EB, 1969, INT J NEUROPHARMACOL, V8, P567

[20]

THOENEN H., 1965, INT J NEUROPHARMAC0L, V4, P79

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