MONITORING OF SUBSTRATES AND PRODUCTS DURING FED-BATCH PENICILLIN FERMENTATIONS ON COMPLEX MEDIA

被引：44

作者：

CHRISTENSEN, LH

NIELSEN, J

VILLADSEN, J

机构：

[1] Department of Biotechnology, Technical University of Denmark

来源：

ANALYTICA CHIMICA ACTA | 1991年 / 249卷 / 01期

关键词：

FLOW SYSTEM; BIOREACTORS; FERMENTATION; MEMBRANE MODULES; PENICILLIN FERMENTATION; PROCESS MONITORING;

D O I：

10.1016/0003-2670(91)87015-Y

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A system used for monitoring of fed-batch penicillin fermentation is characterized. The system includes exhaust gas analysers, a membrane sampling module and analysers measuring dissolved substrate components. Different membrane modules for sampling are examined and compared. An in situ sterilizable membrane module is characterized, and a model describing the now through the unit is proposed. Flow-injection analysers for measuring ammonium and glucose are described and optimized for monitoring samples from penicillin fermentation.

引用

页码：123 / 136

页数：14

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