PRODUCTION OF LEUKOTRIENE-B4 AND 5-HYDROXYEICOSATETRAENOIC ACID BY HUMAN NEUTROPHILS IS INHIBITED BY PSEUDOMONAS-AERUGINOSA PHENAZINE DERIVATIVES

被引：20

作者：

MULLER, M ^{[1
]}

SORRELL, TC ^{[1
]}

机构：

[1] WESTMEAD HOSP,DEPT INFECT DIS & MICROBIOL,WESTMEAD,NSW 2145,AUSTRALIA

来源：

INFECTION AND IMMUNITY | 1991年 / 59卷 / 09期

关键词：

D O I：

10.1128/IAI.59.9.3316-3318.1991

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Pyocyanin, a phenazine pigment produced by Pseudomonas aeruginosa, and its metabolite 1-hydroxyphenazine inhibited leukotriene B4 and 5-hydroxyeicosatetraenoic acid production by up to 70% in human neutrophils stimulated with the calcium ionophore A23187 (5-mu-M). This potential anti-inflammatory effect was dose dependent and occurred at low concentrations (10 to 50-mu-M) that did not inhibit neutrophil viability.

引用

页码：3316 / 3318

页数：3

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