COLOCALIZATION OF BASIC FIBROBLAST GROWTH FACTOR-LIKE IMMUNOREACTIVITY AND ITS RECEPTOR MESSENGER-RNA IN THE RAT SPINAL-CORD AND THE DORSAL-ROOT GANGLION

被引:23
作者
KATO, H [1 ]
WANAKA, A [1 ]
TOHYAMA, M [1 ]
机构
[1] OSAKA UNIV,SCH MED,DEPT ANAT & NEUROSCI,2-2 YAMADAOKA,SUITA,OSAKA 565,JAPAN
关键词
BASIC FGF; FGF RECEPTOR; COLOCALIZATION; MOTOR NEURON; DORSAL ROOT GANGLIA;
D O I
10.1016/0006-8993(92)90704-D
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
In the present study, we examined the localizations of basic fibroblast growth factor-like immunoreactivity (bFGF-LI) and its receptor mRNA in the spinal cord and the dorsal root ganglion of the rat. Anti-bFGF peptide antibody and cRNA probe were employed to visualize the localizations of bFGF-LI and FGF receptor (FGF-R) mRNA, respectively. In the spinal cord, we observed that a number of neurons including the motor neurons and interneurons were positive for both substances. In the dorsal root ganglion (DRG), the large neurons preferentially showed co-localization of bFGF-LI and FGF-R mRNA, while the small neurons were not always positive for both. Given the fact that FGF-R is a membrane-spanning protein, these findings suggest the following two possibilities: (1) bFGF acts on the neurons of the spinal cord and the DRG in an autocrine and/or paracrine manner; (2) FGF-R mRNA-positive neurons take up bFGF from innervating neurons and/or surrounding glias in a receptor-mediated fashion.
引用
收藏
页码:351 / 354
页数:4
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