EVIDENCE THAT THE LARGE NEUTRAL AMINO-ACID L-VALINE DECREASES ELECTRICALLY-EVOKED RELEASE OF 5-HT IN RAT HIPPOCAMPUS INVIVO

被引：51

作者：

GARTSIDE, SE

COWEN, PJ

SHARP, T

机构：

[1] LITTLEMORE HOSP,MRC UNIT CLIN PHARMACOL,OXFORD OX4 4XN,ENGLAND

[2] UNIV OXFORD,LITTLEMORE HOSP,DEPT PSYCHIAT,OXFORD OX4 4XN,ENGLAND

来源：

PSYCHOPHARMACOLOGY | 1992年 / 109卷 / 1-2期

关键词：

5-HT RELEASE; 5-HT SYNTHESIS; AMINO ACIDS; L-TRYPTOPHAN; L-VALINE;

D O I：

10.1007/BF02245511

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

L-Valine competes with tryptophan for transport into the brain and has previously been shown to decrease brain 5-HT synthesis. In the present study, the effect of L-valine on electrically evoked hippocampal 5-HT release was determined in the anaesthetized rat using microdialysis. In control animals two electrical stimulations of the dorsal raphe nucleus 120 min apart (S1 and S2, respectively) released similar amounts of 5-HT. In contrast, in animals which received L-valine (200 mg/kg) between stimulations, S2 released a significantly smaller amount of 5-HT than did S1, although basal 5-HT release was unchanged. The data demonstrate that L-valine decreases the electrically-evoked release of 5-HT in hippocampus in vivo.

引用

页码：251 / 253

页数：3

共 13 条

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