INCONTINENTIA PIGMENTI - CLINICAL AND NEURORADIOLOGIC FEATURES

被引：32

作者：

MANGANO, S

BARBAGALLO, A

机构：

[1] Department of Child Neuropsychiatry, Palermo University, Palermo

来源：

BRAIN & DEVELOPMENT | 1993年 / 15卷 / 05期

关键词：

INCONTINENTIA PIGMENTI; HYPOPLASIA OF CORPUS CALLOSUM; NEURONAL HETEROTOPIA; DESTRUCTIVE ENCEPHALOPATHY;

D O I：

10.1016/0387-7604(93)90122-O

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Developmental brain malformations and destructive processes of unknown etiology were described in incontinentia pigmenti (IP). Two patients, a male and a female, with characteristic skin lesions and central nervous system (CNS) involvement are reported. Neuroradiological examinations revealed hypoplasia of corpus callosum, neuronal heterotopias, and periventricular white matter damage. No specific infectious, inflammatory, or metabolic abnormalities were identified. These neuroradiographic findings may suggest that an ischemic pathogenetic mechanism occurred prenatally. We speculate that the brain damage in IP may occur during CNS development and in successive stages. Magnetic resonance imaging appears more useful to detect white matter lesions and brain malformations in patients with IP.

引用

页码：362 / 366

页数：5

共 23 条

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