A ROLE FOR NITRIC-OXIDE IN THE ANTIULCER ACTIVITY OF CALCITONIN-GENE-RELATED PEPTIDE

被引：15

作者：

CLEMENTI, G ^{[1
]}

CARUSO, A ^{[1
]}

PRATO, A ^{[1
]}

DEBERNARDIS, E ^{[1
]}

FIORE, CE ^{[1
]}

AMICOROXAS, M ^{[1
]}

机构：

[1] UNIV CATANIA,SCH MED,DEPT MED PATHOL 1,I-95125 CATANIA,ITALY

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1994年 / 256卷 / 02期

关键词：

CORP (CALCITONIN GENE-RELATED PEPTIDE); ULCER; NITRIC OXIDE (NO);

D O I：

10.1016/0014-2999(94)90252-6

中图分类号：

R9 [药学];

学科分类号：

1007 [药学];

摘要：

The anti-ulcer activity of calcitonin gene-related peptide (CORP) was inhibited, in a dose-dependent manner, by pretreatment with N-G-nitro-L-arginine methyl ester, an inhibitor of nitric oxide synthase. Our results suggest that endogenous nitric oxide is involved in the anti-ulcer activity of CGRP.

引用

页码：R7 / R8

页数：2

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