DETERMINATION OF CLENBUTEROL IN URINE AS ITS CYCLIC BORONATE DERIVATIVE BY GAS-CHROMATOGRAPHY MASS-SPECTROMETRY

被引:44
作者
POLETTINI, A
RICOSSA, MC
GROPPI, A
MONTAGNA, M
机构
[1] Institute of Legal Medicine, University of Pavia, 27100 Pavia
来源
JOURNAL OF CHROMATOGRAPHY-BIOMEDICAL APPLICATIONS | 1991年 / 564卷 / 02期
关键词
D O I
10.1016/0378-4347(91)80521-D
中图分类号
O65 [分析化学];
学科分类号
070302 ; 081704 ;
摘要
A rapid and reliable gas chromatographic-mass spectrometric method for the determination of clenbuterol in urine is described. Penbutolol was used as internal standard. Four derivatization procedures have been tested, of which 1-butaneboronic acid gave the best results. The method includes extraction of the alkalinized urine (3 ml) with tert.-butyl methyl ether-n-butanol (9:1), derivatization with 1-butaneboronic acid (15 min at room temperature), and analysis in the selected-ion monitoring mode of the derivatives of clenbuterol at m/z 243, 327 and 342 and of penbutolol at m/z 342 and 357. The detection limit is 0.5 ng/ml and the recovery better than 90%.
引用
收藏
页码:529 / 535
页数:7
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