INTRODUCTION OF 5 POTENTIALLY METABOLIZABLE LINKING GROUPS BETWEEN IN-111 CYCLOHEXYL EDTA DERIVATIVES AND F(AB')2 FRAGMENTS OF ANTICARCINOEMBRYONIC ANTIGEN-ANTIBODY .1. A NEW REPRODUCIBLE SYNTHETIC METHOD

被引：9

作者：

GESTIN, JF ^{[1
]}

FAIVRECHAUVET, A ^{[1
]}

MEASE, RC ^{[1
]}

SAIMAUREL, C ^{[1
]}

THEDREZ, P ^{[1
]}

SLINKIN, M ^{[1
]}

MEINKEN, GE ^{[1
]}

SRIVASTAVA, SC ^{[1
]}

CHATAL, JF ^{[1
]}

机构：

[1] BROOKHAVEN NATL LAB,DEPT MED,UPTON,NY 11973

来源：

NUCLEAR MEDICINE AND BIOLOGY | 1993年 / 20卷 / 06期

关键词：

D O I：

10.1016/0969-8051(93)90162-N

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

The purpose of this study was to synthesize new bifunctional linker-chelating agents for the modification of the in vivo distribution of In-111-labeled antibodies. A general simple synthetic method of preparing cyclohexyl EDTA (CDTA) derivatives containing a linker/spacer group is described. Linkers prepared included a diester, a six carbon aliphatic chain, two thioethers and a disulfide group. The CDTA-linker compounds were coupled to F(Ab')2 fragments of anti-carcinoembryonic antigen monoclonal antibody and labeled with In-111 with good retention of immunoreactivity.

引用

页码：755 / 762

页数：8

共 35 条

[1] MONOCLONAL-ANTIBODIES SPECIFIC FOR CARCINOEMBRYONIC ANTIGEN AND PRODUCED BY 2 HYBRID CELL-LINES [J].

ACCOLLA, RS ;

CARREL, S ;

MACH, JP .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1980, 77 (01) :563-566

[2] USE OF ESTERS OF N-HYDROXYSUCCINIMIDE IN PEPTIDE SYNTHESIS [J].

ANDERSON, GW ;

CALLAHAN, FM ;

ZIMMERMAN, JE .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1964, 86 (09) :1839-+

[3]

BLEND MJ, 1988, J NUCL MED, V29, P1810

[4] SYNTHESIS OF 1-(PARA-ISOTHIOCYANATOBENZYL) DERIVATIVES OF DTPA AND EDTA - ANTIBODY LABELING AND TUMOR-IMAGING STUDIES [J].

BRECHBIEL, MW ;

GANSOW, OA ;

ATCHER, RW ;

SCHLOM, J ;

ESTEBAN, J ;

SIMPSON, DE ;

COLCHER, D .

INORGANIC CHEMISTRY, 1986, 25 (16) :2772-2781

[5] MULTICENTER IMMUNOSCINTIGRAPHIC STUDY USING INDIUM-111-LABELED CEA-SPECIFIC AND/OR 19-9 MONOCLONAL-ANTIBODY F(AB')2 FRAGMENTS [J].

CHETANNEAU, A ;

BAUM, RP ;

LEHUR, PA ;

LIEHN, JC ;

PERKINS, AC ;

BARES, R ;

BOURGUET, P ;

HERRY, JY ;

SACCAVINI, JC ;

CHATAL, JF .

EUROPEAN JOURNAL OF NUCLEAR MEDICINE, 1990, 17 (05) :223-229

[6]

COLE WC, 1987, J NUCL MED, V28, P83

[7]

COLE WC, 1986, NUCL MED BIOL, V13, P363

[8] EFFECT OF DIFFERENT LINKAGES BETWEEN CHELATES AND MONOCLONAL-ANTIBODIES ON LEVELS OF RADIOACTIVITY IN THE LIVER [J].

DESHPANDE, SV ;

DENARDO, SJ ;

MEARES, CF ;

MCCALL, MJ ;

ADAMS, GP ;

DENARDO, GL .

NUCLEAR MEDICINE AND BIOLOGY, 1989, 16 (06) :587-597

[9]

ESTEBAN JM, 1987, J NUCL MED, V28, P861

[10] INTRODUCTION OF 5 POTENTIALLY METABOLIZABLE LINKING GROUPS BETWEEN IN-111 CYCLOHEXYL EDTA DERIVATIVES AND F(AB')2 FRAGMENTS OF ANTICARCINOEMBRYONIC ANTIGEN-ANTIBODY .2. COMPARATIVE PHARMACOKINETICS AND BIODISTRIBUTION IN HUMAN COLORECTAL CARCINOMA-BEARING NUDE-MICE [J].

FAIVRECHAUVET, A ;

GESTIN, JF ;

MEASE, RC ;

SAIMAUREL, C ;

THEDREZ, P ;

SLINKIN, M ;

MEINKEN, GE ;

SRIVASTAVA, SC ;

CHATAL, JF .

NUCLEAR MEDICINE AND BIOLOGY, 1993, 20 (06) :763-771

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