INTRODUCTION OF 5 POTENTIALLY METABOLIZABLE LINKING GROUPS BETWEEN IN-111 CYCLOHEXYL EDTA DERIVATIVES AND F(AB')2 FRAGMENTS OF ANTICARCINOEMBRYONIC ANTIGEN-ANTIBODY .1. A NEW REPRODUCIBLE SYNTHETIC METHOD

被引：9

作者：

GESTIN, JF ^{[1
]}

FAIVRECHAUVET, A ^{[1
]}

MEASE, RC ^{[1
]}

SAIMAUREL, C ^{[1
]}

THEDREZ, P ^{[1
]}

SLINKIN, M ^{[1
]}

MEINKEN, GE ^{[1
]}

SRIVASTAVA, SC ^{[1
]}

CHATAL, JF ^{[1
]}

机构：

[1] BROOKHAVEN NATL LAB,DEPT MED,UPTON,NY 11973

来源：

NUCLEAR MEDICINE AND BIOLOGY | 1993年 / 20卷 / 06期

关键词：

D O I：

10.1016/0969-8051(93)90162-N

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

The purpose of this study was to synthesize new bifunctional linker-chelating agents for the modification of the in vivo distribution of In-111-labeled antibodies. A general simple synthetic method of preparing cyclohexyl EDTA (CDTA) derivatives containing a linker/spacer group is described. Linkers prepared included a diester, a six carbon aliphatic chain, two thioethers and a disulfide group. The CDTA-linker compounds were coupled to F(Ab')2 fragments of anti-carcinoembryonic antigen monoclonal antibody and labeled with In-111 with good retention of immunoreactivity.

引用

页码：755 / 762

页数：8

共 35 条

[31] PROGRESS IN RESEARCH ON LIGANDS, NUCLIDES AND TECHNIQUES FOR LABELING MONOCLONAL-ANTIBODIES [J].