ALTERATIONS IN THE SEQUENCE OF THE GENE-4 FROM A HUMAN ROTAVIRUS AFTER MULTIPLE PASSAGES IN HEPG2 LIVER-CELLS

被引:12
作者
KITAMOTO, N [1 ]
MATTION, NM [1 ]
ESTES, MK [1 ]
机构
[1] BAYLOR COLL MED,DIV MOLEC VIROL,1 BAYLOR PLAZA,HOUSTON,TX 77030
关键词
D O I
10.1007/BF01319006
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
The human Wa strain of rotaviruses, initially unable to grow in liver cells, was adapted by multiple passages to grow in HepG2 cells. The genome segment 4 of both the parental and passaged strains was cloned and sequenced. Five amino acid differences (residues 38, 120, 421, 525, and 618) were found in the HepG2-passaged variant compared to the parental Wa strain. Our results support the hypothesis that viral variants that have improved capabilities for infecting liver cells can be generated during infection.
引用
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页码:179 / 185
页数:7
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