STUDIES IN POLYPROPIONATE SYNTHESIS - HIGH PI-FACE SELECTIVITY IN SYN AND ANTI ALDOL REACTIONS OF CHIRAL BORON ENOLATES OF LACTATE-DERIVED KETONES

被引：137

作者：

PATERSON, I

WALLACE, DJ

VELAZQUEZ, SM

机构：

[1] University Chemical Laboratory, Cambridge, CB2 1EW, Lensfield Road

来源：

TETRAHEDRON LETTERS | 1994年 / 35卷 / 48期

关键词：

D O I：

10.1016/0040-4039(94)88434-X

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Use of (c)Hex(2)BCl/Me(2)NEt in the aldol reactions of the alpha'-benzoyloxy ketone 7 with aldehydes leads to high stereoselectivity (97-99.5% ds) for the crystalline anti adducts 11. Under similar conditions, the corresponding benzyl ether 6 favours formation of the syn adducts 9.

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页码：9083 / 9086

页数：4

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