EFFECT OF HYDRALAZINE AND DIHYDRALAZINE ON CONNECTIVE-TISSUE AND BINDING TO SERUM-PROTEIN

被引：2

作者：

BLUMENKRANTZ, N

CHRISTIANSEN, AH

ASBOEHANSEN, G

机构：

[1] University of Copenhagen, Department of Dermatology (with Connective Tissue Research Laboratories), Rigshospital, Copenhagen

来源：

SCANDINAVIAN JOURNAL OF RHEUMATOLOGY | 1979年 / 8卷 / 03期

关键词：

D O I：

10.3109/03009747909114452

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Hydralazine and dihydralazine, chelators of Fe2+, Fe3+ and Mn2+ions, inhibited collagen biosynthesis in organ culture of chicken embryo tibiae. Both substances inhibited the in vitro hydroxylation of [14C]Pro-labelled protocollagen by protocollagen proline hydroxylase. A decreased incorporation of [14C]-D-glucosamine into glyco-and/or muco-proteins was found under the effect of the two drugs. Dihydralazine, a cationic compound, was bound to DNA and acid mucopolysaccharides (glycosaminoglycans), forming an insoluble complex. Both substances were bound to serum arglobulin. Subcutaneous injections of dihydralazine in rats produced a local as well as a general toxic effect. © 1979 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.

引用

页码：177 / 183

页数：7

共 16 条

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