SUBPICOMOLAR AMOUNTS OF NPY(13-36) INJECTED INTO THE NUCLEUS-TRACTUS-SOLITARIUS OF THE RAT COUNTERACT THE CARDIOVASCULAR-RESPONSES TO L-GLUTAMATE

被引：30

作者：

NARVAEZ, JA ^{[1
]}

AGUIRRE, JA ^{[1
]}

FUXE, K ^{[1
]}

机构：

[1] KAROLINSKA INST, DEPT HISTOL & NEUROBIOL, S-10401 STOCKHOLM 60, SWEDEN

来源：

NEUROSCIENCE LETTERS | 1993年 / 151卷 / 02期

关键词：

NEUROPEPTIDE-Y(13-36); NPY-Y2-RECEPTOR; L-GLUTAMATE; MICROINJECTION; BARORECEPTOR; CARDIOVASCULAR; RESPIRATION; RAT; BRAIN;

D O I：

10.1016/0304-3940(93)90016-E

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The effects of NPY(13-36) on cardiorespiratory responses elicited by microinjections of L-glutamate into the nucleus tractus solitarius (NTS) have been studied in anaesthetized (alpha-chloralose + urethane) Sprague-Dawley rats. NPY(13-36) in doses ranging from 50 to 500 fmol produces a significant increase in mean arterial pressure (MAP) without significant effects on heart rate (HR) and respiratory rate (RR). The ED50 dose (100 fmol) of NPY(13-36) counteracts significantly the decrease in MAP and HR elicited by L-glutamate (1500 pmol) microinjected into NTS. Similar results are obtained using a threshold dose of the peptide (50 fmol) and an ED50 dose Of L-glutamate (300 pmol). These results indicate that the Y2 receptors in NTS can mediate vasopressor responses to femtomolar amounts of NPY(13-36) and counteract cardiovascular responses to L-glutamate.

引用

页码：182 / 186

页数：5