THE ROLE OF UROCANIC ACID IN UV-INDUCED IMMUNOSUPPRESSION - RECENT ADVANCES (1992-1994)

被引：114

作者：

NORVAL, M

GIBBS, NK

GILMOUR, J

机构：

[1] UNIV DUNDEE,NINEWELLS HOSP,PHOTOBIOL UNIT,DUNDEE DD1 4HN,SCOTLAND

[2] NORTHWICK PK INST MED RES,HARROW,MIDDX,ENGLAND

来源：

PHOTOCHEMISTRY AND PHOTOBIOLOGY | 1995年 / 62卷 / 02期

关键词：

D O I：

10.1111/j.1751-1097.1995.tb05261.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cis-urocanic acid (UCA), formed in the epidermis by UV irradiation of trans-UCA, has been implicated as a mediator of the immunosuppression induced by UV exposure of the skin. This review covers recent work in which the wavelength dependence of cis-UCA formation, the interaction of UCA isomers with DNA, the effects of UCA isomers on the immune system and their interaction with histamine are examined. Results are frequently conflicting, particularly when considering the possible mode of action of cis-UCA but, overall, a multifaceted role for UCA in immunomodulation by UV radiation is substantiated.

引用

页码：209 / 217

页数：9

共 63 条

[31] HISTAMINE AND CIS-UROCANIC ACID AUGMENT TUMOR-NECROSIS-FACTOR-ALPHA MEDIATED INDUCTION OF KERATINOCYTE INTERCELLULAR-ADHESION MOLECULE-1 EXPRESSION [J].