TRYPTAMINE-4,5-DIONE - PROPERTIES AND REACTION WITH GLUTATHIONE

被引：25

作者：

WONG, KS

DRYHURST, G

机构：

[1] Department of Chemistry, Biochemistry University of Oklahoma, Norman

来源：

BIOORGANIC CHEMISTRY | 1990年 / 18卷 / 03期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/0045-2068(90)90001-L

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

At physiological pH tryptamine-4,5-dione (1), which might be an aberrant metabolite of 5-hydroxytryptamine involved in the etiology of Alzheimer's disease, reacts rapidly with glutathione to give 7-S-(glutathionyl)-tryptamine-4,5-dione (5). Procedures have been devised to isolate 5 and to elucidate its molecular structure using FAB-MS and 1H and 13C NMR spectroscopy. The redox characteristics of 1 and 5 have been elucidated using electrochemical methods. © 1990.

引用

页码：253 / 264

页数：12

共 40 条

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