TRYPTAMINE-4,5-DIONE - PROPERTIES AND REACTION WITH GLUTATHIONE

被引：25

作者：

WONG, KS

DRYHURST, G

机构：

[1] Department of Chemistry, Biochemistry University of Oklahoma, Norman

来源：

BIOORGANIC CHEMISTRY | 1990年 / 18卷 / 03期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/0045-2068(90)90001-L

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

At physiological pH tryptamine-4,5-dione (1), which might be an aberrant metabolite of 5-hydroxytryptamine involved in the etiology of Alzheimer's disease, reacts rapidly with glutathione to give 7-S-(glutathionyl)-tryptamine-4,5-dione (5). Procedures have been devised to isolate 5 and to elucidate its molecular structure using FAB-MS and 1H and 13C NMR spectroscopy. The redox characteristics of 1 and 5 have been elucidated using electrochemical methods. © 1990.

引用

页码：253 / 264

页数：12

共 40 条

[31] SANKER DVS, 1959, FED P AM SOC EXPT BI, V18, P1745
[32] SEROTONINERGIC SYSTEM IN DEMENTIA OF THE ALZHEIMER TYPE - ABNORMAL FORMS OF 5-HYDROXYTRYPTOPHAN AND SEROTONIN IN CEREBROSPINAL-FLUID
VOLICER, L
LANGLAIS, PJ
MATSON, WR
MARK, KA
GAMACHE, PH
[J]. ARCHIVES OF NEUROLOGY, 1985, 42 (12) : 1158 - 1161
[33] EFFECTS OF 5,6-DIHYDROXYTRYPTAMINE ON THE RELEASE, SYNTHESIS, AND STORAGE OF SEROTONIN - STUDIES USING RAT-BRAIN SYNAPTOSOMES
WOLF, WA
BOBIK, A
[J]. JOURNAL OF NEUROCHEMISTRY, 1988, 50 (02) : 534 - 542
[34] A BIOCHEMICAL AND PHARMACOLOGICAL SUGGESTION ABOUT CERTAIN MENTAL DISORDERS
WOOLLEY, DW
SHAW, E
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1954, 40 (04) : 228 - 231
[35] Woolley DW, 1962, BIOCH BASES PSYCHOSE
[36] WRONA MA, 1989, J ORG CHEM, V4, P2718
[37] OXIDATION CHEMISTRY OF 5-HYDROXYTRYPTAMINE .2. MECHANISMS AND PRODUCTS FORMED AT MILLIMOLAR CONCENTRATIONS IN ACIDIC AQUEOUS-SOLUTION
WRONA, MZ
DRYHURST, G
[J]. JOURNAL OF ELECTROANALYTICAL CHEMISTRY, 1990, 278 (1-2) : 249 - 267
[38] OXIDATION CHEMISTRY OF 5-HYDROXYTRYPTAMINE .1. MECHANISM AND PRODUCTS FORMED AT MICROMOLAR CONCENTRATIONS
WRONA, MZ
DRYHURST, G
[J]. JOURNAL OF ORGANIC CHEMISTRY, 1987, 52 (13) : 2817 - 2825
[39] FURTHER INSIGHTS INTO THE OXIDATION CHEMISTRY OF 5-HYDROXYTRYPTAMINE
WRONA, MZ
DRYHURST, G
[J]. JOURNAL OF PHARMACEUTICAL SCIENCES, 1988, 77 (11) : 911 - 917
[40] WRONA MZ, UNPUB

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