ANTIBIOTICS IN THE TREATMENT OF PRETERM LABOR

OBJECTIVE: Clinical evidence for a relationship between chorioamnionitis and the onset of preterm labor, supported by well developed biochemical models of that interaction, motivated a review of prospective, randomized trials of antibiotic use in its prevention. STUDY DESIGN: A literature search was made of antibiotic trials applied to women at risk for preterm labor and with a clinical diagnosis of preterm labor after premature preterm rupture of membranes. A review of two retrospective case-control studies conducted on pregnant women with positive cultures tor Chlamydia trachomatis is also included. RESULTS AND CONCLUSION: Results of antibiotic use in women with preterm premature rupture of membranes supports significant prolongation of the interval from rupture of membranes to delivery and improvement of neonatal outcome in treated patients.