THE SOMNOGENIC LYMPHOCYTE-T SUPPRESSOR PROSTAGLANDIN-D2 IS SELECTIVELY ELEVATED IN CEREBROSPINAL-FLUID OF ADVANCED SLEEPING SICKNESS PATIENTS

被引：96

作者：

PENTREATH, VW ^{[1
]}

REES, K ^{[1
]}

OWOLABI, OA ^{[1
]}

PHILIP, KA ^{[1
]}

DOUA, F ^{[1
]}

机构：

[1] PROJECT RECH CLIN TRYPANOSOMIASE, DALOA, COTE IVOIRE

来源：

TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE | 1990年 / 84卷 / 06期

关键词：

D O I：

10.1016/0035-9203(90)90085-S

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

To help to elucidate the changes induced by Trypanosoma brucei gambiense in the central nervous system (CNS) in advanced sleeping sickness patients, levels of interleukin-1 (IL-1) and prostaglandins D2 (PGD2) and E2 (PGE2) were measured by radio-immunoassay in the cerebrospinal fluid (CSF) from 24 patients diagnosed on the criteria of CSF protein, leucocyte count and parasite presence as having CNS (i.e. late stage) involvement, and from 12 patients without CNS involvement. PGD2 concentrations were selectively and markedly elevated in the late stage patients. The increased PGD2 may in part account for the increased somnolence and the immunosuppression within the CNS. Measurement of PGD2 levels in CSF may be a useful criterion for CNS involvement.

引用

页码：795 / 799

页数：5

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