VALIDATION OF A CAPILLARY ELECTROPHORESIS METHOD FOR THE ENANTIOMERIC PURITY TESTING OF FLUPAROXAN

被引：54

作者：

ALTRIA, KD ^{[1
]}

WALSH, AR ^{[1
]}

SMITH, NW ^{[1
]}

机构：

[1] GLAXO GRP RES LTD,DEPT CHEM ANALYSIS,GREENFORD UB6 0HE,MIDDX,ENGLAND

来源：

JOURNAL OF CHROMATOGRAPHY | 1993年 / 645卷 / 01期

关键词：

D O I：

10.1016/0021-9673(93)80636-M

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A free solution capillary electrophoresis method has been validated for the enantiomeric purity determination of either enantiomer of fluparoxan. The method allowed determination of 1% of either enantiomer in the presence of its stereoisomer. Method validation showed adequate detector linearity over the required range. The method also gave good performance in terms of sensitivity for trace levels of the undesired enantiomers, injection precision and recovery.

引用

页码：193 / 196

页数：4

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