COLLABORATIVE STUDY OF THE ANALYSIS OF TETRACYCLINE BY LIQUID-CHROMATOGRAPHY ON POLY(STYRENE-DIVINYLBENZENE)

被引：14

作者：

HENDRIX, C

ROETS, E

CROMMEN, J

DEBEER, J

PORQUERAS, E

VANDENBOSSCHE, W

HOOGMARTENS, J

机构：

[1] STATE UNIV LIEGE,INST PHARM,DRUG ANAL LAB,B-4000 LIEGE,BELGIUM

[2] STATE UNIV GHENT,ONTLEDING GENEESMIDDELEN MED CHEM LAB,B-9000 GHENT,BELGIUM

[3] DIENST GENEESMIDDELENANALYSE IHE,BRUSSELS,BELGIUM

[4] INST SALUD CARLOS III,CTR NACL FARMACOBIOL,MADRID,SPAIN

来源：

JOURNAL OF LIQUID CHROMATOGRAPHY | 1993年 / 16卷 / 15期

关键词：

Liquid chromatography;

D O I：

10.1080/10826079308019651

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

A previously developed method for the analysis of tetracycline by liquid chromatography on poly(styrene-divinylbenzene) packing materials was examined in a collaborative study involving five laboratories and a total of seven columns. The main compound and the impurities of three tetracycline samples were determined. An analysis of variance, considering each column as a different laboratory, proved absence of consistent laboratory bias. The laboratory-sample interaction was significant. Estimates for the repeatability and the reproducibility of the method, expressed as relative standard deviations of the result of the determination of tetracycline, were calculated to be 0.9 and 1.5% respectively.

引用

页码：3321 / 3329

页数：9