HYALURONAN AND HYALURONECTIN IN THE EXTRACELLULAR-MATRIX OF HUMAN BRAIN-TUMOR STROMA

被引：141

作者：

DELPECH, B

MAINGONNAT, C

GIRARD, N

CHAUZY, C

MAUNOURY, R

OLIVIER, A

TAYOT, J

CREISSARD, P

机构：

[1] INSERM, ICGM CJF 9003, F-75014 PARIS, FRANCE

[2] HOP CHARLES NICOLLE, ANAT PATHOL LAB, F-76000 ROUEN, FRANCE

[3] HOP CHARLES NICOLLE, SERV NEUROCHIRURG, F-76000 ROUEN, FRANCE

来源：

EUROPEAN JOURNAL OF CANCER | 1993年 / 29A卷 / 07期

关键词：

D O I：

10.1016/S0959-8049(05)80214-X

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Hyaluronan (HA) and the hyaluronan-binding glycoprotein hyaluronectin (HN) were measured in 23 gliomas and 8 meningiomas and their location was revisited in 35 tumours. A clear-cut difference was found in the HN/HA ratio values of glioblastomas (below 0.5) and that of astrocytomas (above 0.5 P < 0.001). Besides their location in the intercellular part of gliomas, HA and HN displayed a perivascular location in 1/3 astrocytomas, 17/24 glioblastomas, and 3/7 meningiomas, suggesting they could be produced also by the vascular stroma of tumours and that they would characterise the neoangiogenesis. All cultivated glioma cells tested produced HA in vitro, whereas only 1/11 cell lines produced HN, at a low level. The results obtained suggest that glioma HA and HN are produced by both cancer cells and vascular stroma cells, which contribute to the edification of the extracellular matrix. In meningiomas only the stroma would be responsible for HA and HN production.

引用

页码：1012 / 1017

页数：6

共 29 条

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