REGIONAL SPECIFICITY OF MEMBRANE INSTABILITY IN ALZHEIMERS-DISEASE BRAIN

被引：40

作者：

GINSBERG, L

ATACK, JR

RAPOPORT, SI

GERSHFELD, NL

机构：

[1] NATL INST ARTHRITIS & MUSCULOSKELETAL & SKIN DIS,PHYS BIOL LAB,BETHESDA,MD 20892

[2] NIA,NEUROSCI LAB,BETHESDA,MD 20892

来源：

BRAIN RESEARCH | 1993年 / 615卷 / 02期

关键词：

ALZHEIMERS DISEASE; MEMBRANE; LIPID BILAYER INSTABILITY; NEURODEGENERATION; CRITICAL TEMPERATURE;

D O I：

10.1016/0006-8993(93)90050-W

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We report an inherent tendency towards the destabilisation of cellular membranes in Alzheimer's disease (AD) brain. This tendency is a natural consequence of abnormal membrane lipid composition, which has previously been documented in AD. Membrane destabilisation may contribute to AD pathogenesis in its own right and may also facilitate amyloid beta-protein deposition, which is potentially neurotoxic. The instability was found to co-localise selectively with areas of neurodegeneration in AD brain, thereby possibly accounting for the focal pathology observed in this disorder.

引用

页码：355 / 357

页数：3

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