CONTROLLING THE STEREOCHEMISTRY AT C-15 IN PROSTAGLANDIN SYNTHESIS USING A STEREOCONVERGENT ALLYLSILANE SYNTHESIS AND A SILYL-TO-HYDROXY CONVERSION

被引：16

作者：

FLEMING, I

WINTER, SBD

机构：

[1] Department of Chemistry, Cambridge, CB2 1EW England, Lensfield Road

来源：

TETRAHEDRON LETTERS | 1995年 / 36卷 / 10期

关键词：

D O I：

10.1016/0040-4039(95)00104-K

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The prostaglandin intermediate 2, although giving a mixture of diastereoisomeric alcohols 3 and 4, is converted in a stereoconvergent route using silyl-cuprate chemistry and silyl-to-hydroxy conversion into the alcohol 10.

引用

页码：1733 / 1734

页数：2

共 24 条

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[10] COMPLETE TRANSFER OF CHIRALITY IN THE [3,3]-SIGMATROPIC REARRANGEMENT OF ALLYLIC ACETATES CATALYZED BY PALLADIUM(II) - APPLICATION TO STEREOCONTROLLED SYNTHESES OF PROSTAGLANDINS POSSESSING EITHER THE C-15(S) OR C-15(R) CONFIGURATIO
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