SYNTHESIS OF DEPHOSTATIN, A NOVEL PROTEIN-TYROSINE-PHOSPHATASE INHIBITOR

被引:9
作者
HAMEL, P
GIRARD, Y
机构
[1] Merck Frosst Centre for Therapeutic Research, Pointe-Claire - Dorval, Que. H9R 4P8
关键词
D O I
10.1016/0040-4039(94)88253-3
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
The novel protein tyrosine phosphatase inhibitor dephostatin was synthesized in 6 steps with an overall yield of 35% from 2-nitrohhdroquinone.
引用
收藏
页码:8101 / 8102
页数:2
相关论文
共 6 条
[1]   NEW OBSERVATIONS ON THE ELBS PERSULPHATE OXIDATION [J].
FORREST, J ;
PETROW, V .
JOURNAL OF THE CHEMICAL SOCIETY, 1950, (SEP) :2340-2342
[2]   DEPHOSTATIN, A NOVEL PROTEIN-TYROSINE-PHOSPHATASE INHIBITOR PRODUCED BY STREPTOMYCES .1. TAXONOMY, ISOLATION, AND CHARACTERIZATION [J].
IMOTO, M ;
KAKEYA, H ;
SAWA, T ;
HAYASHI, C ;
HAMADA, M ;
TAKEUCHI, T ;
UMEZAWA, K .
JOURNAL OF ANTIBIOTICS, 1993, 46 (09) :1342-1346
[3]   DEPHOSTATIN, A NOVEL PROTEIN-TYROSINE-PHOSPHATASE INHIBITOR PRODUCED BY STREPTOMYCES .2. STRUCTURE DETERMINATION [J].
KAKEYA, H ;
IMOTO, M ;
TAKAHASHI, Y ;
NAGANAWA, H ;
TAKEUCHI, T ;
UMEZAWA, K .
JOURNAL OF ANTIBIOTICS, 1993, 46 (11) :1716-1719
[4]   REDUCTION WITH SODIUM BOROHYDRIDE-TRANSITION METAL SALT SYSTEMS .1. REDUCTION OF AROMATIC NITRO-COMPOUNDS WITH THE SODIUM BOROHYDRIDE-NICKELOUS CHLORIDE SYSTEM [J].
NOSE, A ;
KUDO, T .
CHEMICAL & PHARMACEUTICAL BULLETIN, 1981, 29 (04) :1159-1161
[5]   DARSTELLUNG VON NITROSAMINEN, ALKYLNITRITEN UND ALKYLNITRATEN MIT NITROSYL BZW NITRYL-TETRAFLUORO-BORAT [J].
OLAH, G ;
NOSZKO, L ;
KUHN, S ;
SZELKE, M .
CHEMISCHE BERICHTE-RECUEIL, 1956, 89 (10) :2374-2377
[6]  
UMEZAWA, 1994, J CHEMS OC CHEM COMM, P437