INHIBITION OF MITOCHONDRIAL ATPASE BY DICARBOPOLYBORATE, A NEW ENZYME-INHIBITOR

被引：9

作者：

DRAHOTA, Z

MARES, V

RAUCHOVA, H

SAF, P

KALOUS, M

机构：

[1] Institute of Physiology, Academy of Sciences, Prague-4

来源：

JOURNAL OF BIOENERGETICS AND BIOMEMBRANES | 1994年 / 26卷 / 05期

关键词：

POLYBORATE ANIONS; MITOCHONDRIA; F0F1-ATPASE;

D O I：

10.1007/BF00762743

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

Polyborate anions were found to inhibit mitochondrial ATPase. Mercapto and chloro derivatives of dicarbononaborates showed full inhibition of the enzyme activity at 0.5-0.8 mM. The inhibitory effect of dodecaborates was lower. The inhibition was of competitive type with respect to ATP. The inhibition of soluble F-1-ATPase indicates a direct interaction of the polyborate anion with the catalytic part of the enzyme molecule.

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页码：583 / 586

页数：4

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