RAT PINEAL GS-ALPHA, GI-ALPHA AND GO-ALPHA - RELATIVE ABUNDANCE AND DEVELOPMENT

被引：13

作者：

BABILA, T ^{[1
]}

SCHAAD, NC ^{[1
]}

KLEIN, DC ^{[1
]}

机构：

[1] NICHHD,DEV NEUROBIOL LAB,NEUROENDOCRINOL SECT,BETHESDA,MD 20892

来源：

BRAIN RESEARCH | 1992年 / 572卷 / 1-2期

关键词：

GS; GI; GO; GTP-BINDING PROTEIN; PINEAL; DEVELOPMENT;

D O I：

10.1016/0006-8993(92)90474-N

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The adult rat pineal gland contains relatively high concentrations of Gs-alpha, low amounts of both Gi-alpha and Go-alpha, and undetectable levels of GT-alpha. During development the amounts of 45 kDa Gs-alpha and of Gi-alpha remain constant. In contrast, 42 kDa Gs-alpha and Go-alpha are nearly absent at birth and increase in abundance markedly thereafter. GT-alpha is undetectable at any age. It would appear that multiple mechanisms regulate the expression of G-proteins in the pineal gland.

引用

页码：232 / 235

页数：4

共 24 条

[1]

AUERBACH DA, 1982, MELATONIN RHYTHM GEN, P97

[2]

BRADFORD MM, 1976, ANAL BIOCHEM, V72, P248, DOI 10.1016/0003-2697(76)90527-3

[3] MECHANISM OF CHOLERA TOXIN ACTION - COVALENT MODIFICATION OF GUANYL NUCLEOTIDE-BINDING PROTEIN OF ADENYLATE-CYCLASE SYSTEM [J].

CASSEL, D ;

PFEUFFER, T .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1978, 75 (06) :2669-2673

[4]

CODINA J, 1984, ADV CYCLIC NUCL PROT, V17, P111

[5] G-PROTEINS AND DUAL CONTROL OF ADENYLATE-CYCLASE [J].

GILMAN, AG .

CELL, 1984, 36 (03) :577-579

[6]

GOLDSMITH P, 1988, J BIOL CHEM, V263, P6476

[7] PURIFICATION OF HETEROTRIMERIC GTP-BINDING PROTEINS FROM BRAIN - IDENTIFICATION OF A NOVEL FORM OF G0 [J].

GOLDSMITH, P ;

BACKLUND, PS ;

ROSSITER, K ;

CARTER, A ;

MILLIGAN, G ;

UNSON, CG ;

SPIEGEL, A .

BIOCHEMISTRY, 1988, 27 (18) :7085-7090

[8]

GOLDSMITH P, 1987, J BIOL CHEM, V262, P14683

[9] THE MELATONIN RHYTHM GENERATING-SYSTEM - DEVELOPMENTAL ASPECTS [J].

KLEIN, DC ;

NAMBOODIRI, MAA ;

AUERBACH, DA .

LIFE SCIENCES, 1981, 28 (18) :1975-1986

[10]

KLEIN DC, 1985, PHOTOPERIODISM MELAT, P38

← 1 2 3 →