VITAMIN-D OVERLOAD AND EXPERIMENTAL TRYPANOSOMA-CRUZI INFECTION - PARASITOLOGICAL AND HISTOPATHOLOGICAL ASPECTS

被引:13
作者
SILVA, ME
SILVA, MEC
SILVA, ME
NICOLI, JR
BAMBIRRA, EA
VIEIRA, EC
机构
[1] UNIV FED MINAS GERAIS,INST CIENCIAS BIOL,DEPT BIOQUIM & IMUNOL,GNOTOBIOL LAB,CP 2486,BR-30161 BELO HORIZON,BRAZIL
[2] UNIV FED OURO PRETO,ESCOLA FARM,DEPT NUTR,BR-35400 OURO PRETO,MG,BRAZIL
[3] UNIV FED MINAS GERAIS,FAC MED,DEPT ANAT PATOL,BR-30161 BELO HORIZON,MG,BRAZIL
来源
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-PHYSIOLOGY | 1993年 / 104卷 / 01期
关键词
D O I
10.1016/0300-9629(93)90026-Z
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
1. Six groups of 45-day-old, 23.0 +/- 1.7 g, female Balb/c mice were inoculated intraperitoneally with 63, 252, 440, 630, 2520 or 6300 l.U. of vitamin D for 6 days. A seventh group was inoculated with saline. Each group consisted of 30 animals. 2. All animals inoculated with the doses of 2520 and 6300 and 70% of mice which received 630 I.U. of vitamin D died 21 days after the first administration of the vitamin. The LD50 was 630 I.U. 3. The survivors were divided into two groups inoculated intraperitoneally with 5000 trypomastigotes of either Y or CL strain of Trypanosoma cruzi. 4. Based on the survival index on day 73 after infection, Vitamin D gave statistically significant protection (P < 0.01) for mice inoculated with doses of 63 or 430 I.U. of Y or CL strains, respectively. 5. On histopathological examination, inflammatory reaction and cellular and tissue parasitism were less intense in animals which received higher doses of vitamin D. 6. It is concluded that an overload of vitamin D had a protective effect against CL and Y strains of Trypanosoma cruzi infection in Balb/c mice.
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页码:175 / 181
页数:7
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