EFFECT OF BETA-CAROTENE ON CLASTOGENIC EFFECTS OF MITOMYCIN-C, METHYL METHANESULFONATE AND BLEOMYCIN IN CHINESE-HAMSTER OVARY CELLS

被引:30
作者
SALVADORI, DMF
RIBEIRO, LR
NATARAJAN, AT
机构
[1] LEIDEN STATE UNIV,SYLVIUS LAB,MGC,DEPT RADIAT GENET & CHEM MUTAGENESIS,2333 AL LEIDEN,NETHERLANDS
[2] UNIV FED BAHIA,SCH VET,TOXICOL & GENET TOXICOL LAB,BR-40210 SALVADOR,BA,BRAZIL
关键词
D O I
10.1093/mutage/9.1.53
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
The effect of beta-carotene on the frequencies of micronuclei (MN) induced in cytochalasin blocked binucleated Chinese hamster ovary cells (CHO) by a bifunctional alkylating agent mitomycin C (MMC), a monofunctional alkylating agent methyl methanesulphonate (MMS) and a radio-mimetic agent bleomycin (BLEO) was investigated. Four different modes of application of the combination of clastogens and beta-carotene were examined (pre-treatment, simultaneous treatment, pre- + simultaneous treatment and post-treatment). The results obtained showed no effect of beta-carotene on the frequencies of MN induced by MMS, a slight but not statistically significant reduction of MMC-induced MN only when beta-carotene was used in low concentrations (0.25 and 0.5 mu M) and a potentiation of the clastogenicity of bleomycin by beta-carotene in three of the treatment regimes utilized, post-treatment being ineffective. On the basis of these results it can be concluded that the effect of beta-carotene on clastogenesis induced by chemicals depends on the type and mechanism of action of the clastogen used as well as the treatment protocol employed.
引用
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页码:53 / 57
页数:5
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