IDENTIFICATION AND CHARACTERIZATION OF PARATHYROID-HORMONE PARATHYROID HORMONE-RELATED PEPTIDE RECEPTOR IN CULTURED ASTROCYTES

被引：27

作者：

HASHIMOTO, H ^{[1
]}

AINO, H ^{[1
]}

OGAWA, N ^{[1
]}

NAGATA, S ^{[1
]}

BABA, A ^{[1
]}

机构：

[1] OSAKA UNIV,FAC PHARMACEUT SCI,DEPT PHARMACOL,SUITA,OSAKA 565,JAPAN

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1994年 / 200卷 / 02期

关键词：

D O I：

10.1006/bbrc.1994.1555

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Parathyroid hormone (PTH)/parathyroid hormone-related peptide (PTHrP) receptor expressed in rat cultured cortical type I astrocytes was identified and characterized. Northern blot analysis demonstrated that the PTH/PTHrP receptor mRNA is expressed in astrocytes. A human PTH fragment, PTH[1-34], stimulated adenylate cyclase with the EC(50) value of 3 nM, but not phospholipase C. PTH[1-34] changed the morphology of protoplasmic type astrocytes into process-bearing ones. Thus, type I astrocytes possess PTH/PTHrP receptor that is coupled to an adenylate cyclase-activating system but not to phospholipase C. (C) 1994 Academic Press, Inc.

引用

页码：1042 / 1048

页数：7