CONFORMATION, PARTITION, AND DRUG DESIGN

被引：14

作者：

DAVIES, RH

SHEARD, B

TAYLOR, PJ

机构：

[1] Pharmaceuticals Division Pharmaceuticals Div, Macclesfield, Cheshire, SK10 4TG, I.C.I. Alderley Park

来源：

JOURNAL OF PHARMACEUTICAL SCIENCES | 1979年 / 68卷 / 03期

基金：

美国国家卫生研究院;

关键词：

Conformations—drug; biological activity; fraction of conformer and partition coefficient; Partition coefficients—drug conformers; structure‐activity relationships; Structure‐activity relationships—drug conformers;

D O I：

10.1002/jps.2600680345

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

[No abstract available]

引用

页码：396 / 397

页数：2

共 16 条

[1] ROTATIONAL-ISOMERISM .13. ROTATIONAL-ISOMERISM IN FURFURALDEHYDE
ABRAHAM, RJ
SIVERNS, TM
[J]. TETRAHEDRON, 1972, 28 (11) : 3015 - &
[2] ABRAHAM RJ, 1974, INTERNAL ROTATION MO
[3] DAVIES RH, 1977, INT J QUANTUM CHEM, V4, P413
[4] ELBERMANI MF, 1970, J AM CHEM SOC, V92, P6750
[5] CONFORMATION OF HISTAMINE DERIVATIVES .3. RELATIONSHIP BETWEEN CONFORMATION AND PHARMACOLOGICAL ACTIVITY
GANELLIN, CR
[J]. JOURNAL OF MEDICINAL CHEMISTRY, 1973, 16 (06) : 620 - 623
[6] RHO-SIGMA-PI ANALYSIS . METHOD FOR CORRELATION OF BIOLOGICAL ACTIVITY + CHEMICAL STRUCTURE
HANSCH, C
FUJITA, T
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1964, 86 (08) : 1616 - &
[7] Hansch C., 1971, DRUG DESIGN, V1
[8] Kier L. B., 1971, MOL ORBITAL THEORY D
[9] PARTITION COEFFICIENTS AND THEIR USES
LEO, A
HANSCH, C
ELKINS, D
[J]. CHEMICAL REVIEWS, 1971, 71 (06) : 525 - +
[10] MAUTNER HC, 1974, MOL QUANTUM PHARMACO

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