RELATIONSHIP BETWEEN SCHISTOSOMICIDAL DRUG EFFICACY, GONADAL-STEROID HORMONAL CHANGES AND STATE OF DISEASE IMMUNOPATHOLOGY IN MURINE SCHISTOSOMIASIS-MANSONI

被引：3

作者：

BOTROS, SS ^{[1
]}

SALAMA, SH ^{[1
]}

ESTAFAN, MY ^{[1
]}

GOMAA, NE ^{[1
]}

METWALLY, AA ^{[1
]}

EBEID, FA ^{[1
]}

机构：

[1] NATL RES CTR,DEPT PHARMACOL,CAIRO,EGYPT

来源：

PHARMACOLOGICAL RESEARCH | 1990年 / 22卷 / 03期

关键词：

immunopathology; Schistosoma mansoni; schistosomicidal drugs; sex hormones;

D O I：

10.1016/1043-6618(90)90734-U

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The schistosomicidal efficacy of praziquantel (2 × 500 mg/kg), oxamniquine (1 × 100 mg/kg) and combined one-third the curative dose of each of them (333 mg/kg praziquantel+33 mg/kg oxamniquine), were correlated to gonadal steroid hormonal changes and state of disease immunopathology, in mice infected with 100Schistosoma mansoni (S. mansoni) cercariae. Maximum efficacy recorded with combination regimen particularly 4 weeks after treatment, was accompanied by maximum reduction in granuloma volume (65%), least fall in testosterone level (-56·2 and -60·2% in male and female mice respectively) and increased progesterone level (+ 33 · 9 and + 81 · 5% in male and female mice respectively). These findings revealed a potentiated effect of combination therapy on mature infection and the possible involvement of gonadal steroid hormones in affecting the efficacy of schistosomicidal drugs and state of disease immunopathology. © 1990 The Italian Pharmacological Society.

引用

页码：359 / 370

页数：12

共 37 条

[1]

Abraham G.E., 1981, RADIOASSAY SYSTEM CL, P475

[2]

AHLQVIST J, 1976, ACTA ENDOCRINOL S6, V20, P33

[3]

ANDRADE ZA, 1986, AM J PATHOL, V124, P59

[4]

BARRABES A, 1979, CR SOC BIOL, V173, P153