RELATIONSHIP BETWEEN SCHISTOSOMICIDAL DRUG EFFICACY, GONADAL-STEROID HORMONAL CHANGES AND STATE OF DISEASE IMMUNOPATHOLOGY IN MURINE SCHISTOSOMIASIS-MANSONI

被引:3
作者
BOTROS, SS [1 ]
SALAMA, SH [1 ]
ESTAFAN, MY [1 ]
GOMAA, NE [1 ]
METWALLY, AA [1 ]
EBEID, FA [1 ]
机构
[1] NATL RES CTR,DEPT PHARMACOL,CAIRO,EGYPT
关键词
immunopathology; Schistosoma mansoni; schistosomicidal drugs; sex hormones;
D O I
10.1016/1043-6618(90)90734-U
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
The schistosomicidal efficacy of praziquantel (2 × 500 mg/kg), oxamniquine (1 × 100 mg/kg) and combined one-third the curative dose of each of them (333 mg/kg praziquantel+33 mg/kg oxamniquine), were correlated to gonadal steroid hormonal changes and state of disease immunopathology, in mice infected with 100Schistosoma mansoni (S. mansoni) cercariae. Maximum efficacy recorded with combination regimen particularly 4 weeks after treatment, was accompanied by maximum reduction in granuloma volume (65%), least fall in testosterone level (-56·2 and -60·2% in male and female mice respectively) and increased progesterone level (+ 33 · 9 and + 81 · 5% in male and female mice respectively). These findings revealed a potentiated effect of combination therapy on mature infection and the possible involvement of gonadal steroid hormones in affecting the efficacy of schistosomicidal drugs and state of disease immunopathology. © 1990 The Italian Pharmacological Society.
引用
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页码:359 / 370
页数:12
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